Epidemiological and Pathological Study on Mediastinal Masses Through a Ten-year Time Period (2001-2011) in Sari (North of Iran)


1 Associate Professor of Pathology, Pathology Department of Imam Khomeini hospital, Sari, Iran.

2 Department of Thoracic Surgery, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

3 School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.


Introduction: Mediastinal masses divided into three major categories, inflammatory masses, cysts and tumors. Meanwhile, the tumors in the most dangerous. The aim of this study was to assess demographic characteristics, clinical signs and histopathology in patients with mediastinal masses.
Materials and methods: we design a retrospective study between the 2001-2011 in sari (north of Iran) to review patient records and pathology reports that they have mediastinal masses.
Results: This study consist of 60 patients with mean age of 40.41±17.58 years. 41.7% patients were between 20-40 years old age. our study show that exist of the 56.7% of mass in anterior mediastinum, 21.7% in medial mediastinum and the 21.7% in posterior mediastinum. the most common clinical manifestation was cough (28.3%), dyspnea (21.7%) and pain (18.3%). furthermore, 8 patients (13.3%) don’t have any clinical manifestation. lymphoma (36.7%), thymoma (11.7%) and metastatic cancer (10%) were common tumors. a significant difference between the age and tumor type was detected (P=0.033).
Conclusion: our study showed that the mediastinum mass more involvement patient in the 3 and 4 dace of their age. the common clinical manifestation was cough and dyspnea. the major cusses of mediastinal mass were tumors and the common tumors type included lymphoma, thymoma and metastases.